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Curry spice boosts exercise performance in mice with heart failure

30 Nov 2018 New research suggests that curcumin, a main ingredient in curry, may improve exercise intolerance related to heart failure. The study is published ahead of print in the Journal of Applied Physiology.

Curcumin, a chemical that comes from the turmeric plant, has been used as a traditional Asian medicine for centuries, primarily to treat gastrointestinal ailments and skin wounds. Studies increasingly suggest that the compound may prevent or limit muscle wasting associated with a number of health conditions, including heart failure.

People with heart failure have a reduced function of the left ventricle – the chamber of the heart that pumps blood out to the rest of the body – called reduced ejection fraction. A decreased ability to exercise (exercise intolerance) is another significant characteristic of heart failure.

Researchers from the University of Nebraska Medical Center in the US examined the effects of curcumin on a mouse model of heart failure with reduced ejection fraction.

One group of mice with heart failure received daily doses of curcumin for 12 weeks, and another group did not receive treatment. The heart failure groups were compared to a control group of healthy mice that received curcumin and an untreated control group.

The research team measured the exercise capacity of all the mice before and after curcumin treatment. The researchers also examined muscle fiber samples to assess enzyme expression levels. They found that expression of Nrf2 – a protein that regulates the expression of antioxidant enzymes – increased, and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin.

In addition, both groups that received curcumin – even the animals without heart failure – had improved exercise capacity when compared with the untreated groups, suggesting the effects of curcumin on skeletal muscle is not exclusive to heart failure.

"These data suggest that activation of Nrf2 in skeletal muscle may represent a novel therapeutic strategy to improve ... quality of life" in people with heart failure with reduced ejection fraction, the researchers wrote.